Sephardic Monograph Series™ ISSN # 1552-955X

The Sephardic Monograph Series™ consists of monographs issued on Sephardic oriented topics which are of interest to the Jewish community. Topics may revolve around either historic or contemporary nonfiction subject matter. The Sephardic Monograph Series™ will contain its own International Standard Serial Number (ISSN) and each individual edition will have a unique ISBN number. Each issue is approximately 50-150 pages and produced as a Perfect Bound serialized volume. Each monograph will carry both an ISBN (unique to each monograph) and an ISSN (to cover the entire series).

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Monograph No. 1 BIBLIOGRAPHY OF ETHNIC SEPHARDIC JEWS IN THE MEDICAL LITERATURE ISBN # 0-9763226-0-9: 210 pages. December 2004 by Shelomo Alfassa and Houman Kashani M.D.

Bibliography of Ethnic Sephardic Jews in the Medical Literature covers a distinct subject area of biomedicine. Relevance to the subject of the Sephardic Jews is the only criterion for inclusion of works in this document; the format, ownership, or location of the material were not considered. This Monograph contains selected references to journal articles published from 1956 through October 2004. Letters to the editor and meeting abstracts found in the available data pool were excluded for the sake of continuity. The various medical topics have been arranged under logical subject categories that reflect appropriate divisions. The only exception is the discipline of genetics which is sub-divided because of its large size. Although an abstract theoretically may qualify to fall into more than one division, the editors have made certain each citation only appears under one category, that being the most significant topic spoken of inside the respective abstract.

Data is presented in this book as a resource for those wishing to conduct further research and/or examine what research has been conducted which makes mention of the Sephardim as study participants, case studies which compare the Sephardim to other Jewish populations or even non-Jewish populations. This Monograph contains not only studies conducted on Sephardim, but often topics of other research where Sephardim are singled out, mentioned, or measured against a particular set. Many times, Sephardim will act as a control group for a primary study on Ashkenazim. In one notable case, a group of 552 non-Ashkenazim served as the control.

A Note About Genetics

Genetic research technology is evolving at an exponential rate and for this reason the reader will find the largest portion of this book dedicated to this topic. Jewish 'genetics' remains a subject which continues to develop rapidly. In this branch of biology that deals with heredity, especially the mechanisms of hereditary transmission and the variation of inherited characteristics among similar or related organisms, the genetic constitution of an individual, class, or group (in this case the Sephardim) is explored. Genetic studies classify the Israeli Jewish population into two major groups: Ashkenazi from Central and Eastern Europe and Sephardic or non-Ashkenazi, from the Mediterranean and North Africa. Infrequently known scientific terms such as Moroccan mutation, Tunisian mutation and Moorish substrate exist within the medical literature to help define and distinguish genetic markers found in scientific research. Many times, these terms are used in regards to both Sephardim, as well as for Arab population members of those lands. Genetic science has demonstrated fascinating conclusions, connecting migration and history with biomedicine. Examples of portions of abrstracts include:

Since Iraqui-Jews represent the original gene pool of Jews who lived in Babylon 2500 years ago we hypothesize that the type II mutation is ancient and that the type III mutation occurred more recently, after the divergence of the original Babylonian Jews into Ashkenazi, Sephardic (Spanish) and Middle Eastern Jews.

It is shown that there is a 'Moorish substrate' in the eastern and north-eastern parts of Spain and in southern Portugal. Serological effects, such as could derive from the assimilation of a large Jewish population, cannot be identified in the data available. The theory that most Hispano-Moslems and Spanish Jews were of indigenous origin is not gainsaid by the serological data available.

The ancestor of modern I1307K alleles existed 87.9-118 generations ago (approximately 2,200-2,950 years ago). This age estimate indicates that I1307K existed at about the time of the beginning of the Jewish diaspora, explaining its presence in non-Ashkenazi populations.

These findings suggest that the pemphigus MHC susceptibility gene among Iranians derived from the same ancestor as that in the Ashkenazim. The ancient Jews were under Persian domination from 500 B.C. until 300 B.C. and in the 8th century A.D., a Tataric people living in the kingdom of Khazar on the Western shore of the Caspian Sea and the Northern shore of the Black Sea, near Persia, converted to Judaism, providing possible opportunities for gene mixing in two populations that are distinct and separate today.

High proportion of the CF [Cystic Fibrosis] chromosomes can be identified in Ashkenazi Jews (95%), Jews originating from Tunisia (100%), Libya (91%), Turkey (90%), and Georgia (88%).

Because non-Ashkenazi Jews in Israel are of lower socioeconomic status than Ashkenazi Jews, we stratified our patients according to their socioeconomic parameters, median HbA1 values, and duration of diabetes. Non-Ashkenazi patients were at a higher risk to develop complications in all strata.

Our results have shown that, to a remarkable extent, they have retained their biological identity, with a unique pattern, in terms of gene and haplotype frequencies, separate from the other populations of Majorca. The Chuetas were found to be more related to Moroccan and Libyan Jews than other Majorcans.

This research aims to examine whether there are differences in the level of anxiety, the perception of danger, the reliance on security forces and signs of psychological distress during times of war between two groups of Holocaust survivors: Jews of Greece and Jews of Eastern and Western Europe, while assessing their psychological ability to cope with the wave of terrorism against the Israeli population.

This book is not yet for sale but is expected to be by February 2005.

(The above extracts of selected abstracts included in BIBLIOGRAPHY OF ETHNIC SEPHARDIC
have had their footnotes/citations removed for this Intenet page only).



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